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Correlation between cytoplasmic steroid receptors and tumour differentiation and invasion in endometrial carcinoma
Author(s) -
QUINN M. A.,
PEARCE P.,
FORTUNE D. W.,
KOH S. H.,
HSIEH C.,
CAUCHI M.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01115.x
Subject(s) - adenosquamous carcinoma , receptor , adenocarcinoma , androgen receptor , cytoplasm , sex hormone receptor , biology , carcinoma , androgen , progesterone receptor , medicine , endocrinology , pathology , cancer research , estrogen receptor , cancer , hormone , prostate cancer , breast cancer , microbiology and biotechnology
Summary. The incidence and levels of cytoplasmic steroid receptors were studied in 155 endometrial carcinomas: oestrogen receptors (ER) were measured in all samples, progesterone receptors (PR) in 148 and androgen receptors (AR) in 118. Well‐differentiated adenocarcinomas were significantly more likely to contain ER, PR and AR than were poorly‐differentiated tumours, and mean values of ER and PR content were significantly higher in well‐differentiated adenocarcinomas than in less‐differentiated tumours. Receptor profiles in adenosquamous carcinomas and clear‐cell carcinomas were similar to those in adenocarcinomas. Deeply invasive tumours were significantly less likely to be ER, PR or AR positive and, even when positive, such tumours had significantly lower mean levels of ER and PR. Poorly‐differentiated tumours were significantly more likely to be ER‐negative PR‐positive than well‐differentiated adenocarcinomas and adenosquamous carcinomas.