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Reduced in‐vitro fertilization of human oocytes from patients with raised basal luteinizing hormone levels during the follicular phase
Author(s) -
STANGER JAMES D.,
YOVICH JOHN L.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01113.x
Subject(s) - luteinizing hormone , follicular phase , in vitro fertilisation , human fertilization , menotropins , infertility , embryo transfer , ovulation , andrology , endocrinology , follicle stimulating hormone , medicine , basal (medicine) , gonadotropin , oocyte , unexplained infertility , biology , hormone , ovulation induction , pregnancy , embryo , anatomy , insulin , genetics , microbiology and biotechnology
Summary. A series of 62 women were managed in the University of Western Australia/PIVET Laboratory in‐vitro fertilization programme. In 60 of them follicle growth was stimulated with clomiphene citrate’ with or without additional human menopausal gonadotrophin (hMG) and in two with hMG alone. Follicles were aspirated at laparoscopy following an hCG trigger injection and occasionally following a spontaneous luteinizing hormone (LH) surge. Oocytes were inseminated with 0·5×10 5 −10 5 sperm/ml 3–6 h later. A significant reduction ( P <0·001) in the fertilization rate of mature oocytes was observed in those patients whose basal serum LH values were >1 SD above the mean. Fifty‐nine women subsequently had embryo transfer and of 10 clinical pregnancies, none occurred in those with elevated LH values. Reduced fertilization may be a reflection of premature oocyte maturation or ageing. This may have clinical implications in the management of some patients with unexplained infertility.