Premium
Radionuclide imaging of ovarian tumours with 123 I‐labelled monoclonal antibody (NDOG 2 ) directed against placental alkaline phosphatase
Author(s) -
DAVIES J. O.,
DAVIES E. R.,
HOWE K.,
JACKSON P. C.,
PITCHER E. M.,
SADOWSKI C. S.,
STIRRAT G. M.,
SUNDERLAND C. A.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01095.x
Subject(s) - alkaline phosphatase , monoclonal antibody , placental alkaline phosphatase , pathology , ovarian carcinoma , abnormality , chemistry , biology , antibody , medicine , ovarian cancer , enzyme , cancer , biochemistry , immunology , psychiatry
Summary. A radiolabelled monoclonal antibody (NDOG,) directed against placental alkaline phosphatase (PLAP) was used in the radio‐immunodetection of ovarian carcinoma. Tumour deposits were successfully visualized in 11 of 15 patients and the abnormalities demonstrated were classified as focal or diffuse. Of the 11 patients, eight showed focal abnormalities alone and three had a diffuse abnormality, of which two also showed a focal abnormality. False‐positive results may occur not only due to uptake of 123 I by gut mucosa and an inadequately blocked thyroid gland but also from activity in an incompletely emptied bladder. A false‐negative result occurred due to high background activity in the liver masking a known, discrete tumour deposit.