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Clinical implications for immunoscintigraphy in patients with ovarian malignancy: a preliminary study using monoclonal antibody 791T/36
Author(s) -
SYMONDS E. M.,
PERKINS A. C.,
PIMM M. V.,
BALDWIN R. W.,
HARDY J. G.,
WILLIAMS D. A.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01094.x
Subject(s) - immunoscintigraphy , medicine , ovarian carcinoma , monoclonal antibody , ovary , radiology , malignancy , antibody , carcinoma , pathology , nuclear medicine , ovarian cancer , cancer , radioimmunotherapy , immunology
Summary. Twelve patients with suspected primary and recurrent carcinoma of the ovary have undergone immunoscintigraphy with an anti‐tumour monoclonal antibody in order to assess the impact of the technique on patient management. Consistent tumour uptake of radiolabelled antibody was visualized in malignant tumours after subtraction of the blood background activity. Eight patients were imaged before surgery and in all of these the sites of uptake visualized on the images agreed with the surgical findings. In one patient with recurrent disease the imaging information was used as an aid for establishing the extent of external beam radiotherapy. A repeat study in this patient 6 months later revealed a reduction in the size of the tumour, which still concentrated labelled antibody and confirmed the viability of repeat investigations. Immunoscintigraphy was capable of providing diagnostic information which may offer an alternative to second‐look surgery in these patients.