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Dramatic increase of placental protein 5 levels following injection of small doses of heparin
Author(s) -
MENABAWEY M.,
SILMAN R.,
RICE A.,
CHARD T.
Publication year - 1985
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1985.tb01083.x
Subject(s) - heparin , hormone , basal (medicine) , placenta , cannula , medicine , endocrinology , pregnancy , secretion , physiology , biology , fetus , surgery , insulin , genetics
Summary. In the course of an investigation on the effects of thyroid releasing hormone in pregnant women we noted a dramatic increase in the levels of placental protein 5 (PP5) in maternal blood. This increase ranged from 10 times to over 40 times the basal levels. Further study showed that the rise was associated with the use of heparin to maintain the patency of the cannula through which the samples were collected. Furthermore, the phenomenon appeared to be systemic rather than local, and may well be due to a direct effect of heparin on PP5 secretion by the placenta.