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Endocrine effects of danazol in the treatment of endometriosis
Author(s) -
BEVAN J. R.,
DOWSETT M.,
JEFFCOATE S. L.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb05901.x
Subject(s) - danazol , sex hormone binding globulin , endocrine system , luteinizing hormone , endometriosis , endocrinology , medicine , hormone , globulin , androgen
summary The effects of danazol therapy on circulating gonadotrophins, oestradiol and sex hormone‐binding globulin (SHBG) binding capacity have been studied in eight patients with endometriosis. There was a significant rise in luteinizing hormone (LH) in the first week of treatment with a fall in oestradiol levels. There was a marked fall in SHBG in the first week which continued up to 4 weeks. It is concluded that danazol is not ‘antigonadotrophic’ as frequently claimed and that its therapeutic actions, side effects and the endocrine changes could be explained by an effect on SHBG production. The rationale of its use in other conditions requires reconsideration.