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Diurnal variation of uterine contractility
Author(s) -
LUNDSTRÖM V.,
ENEROTH P.,
SWAHN M.L.,
GRANSTRÖM E.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb05900.x
Subject(s) - endocrinology , medicine , prolactin , metabolite , menstrual cycle , contractility , vasopressin , hormone , circadian rhythm , endogeny , chemistry , biology
summary The diurnal uterine activity in four normal women in the secretory phase of their menstrual cycles and one woman suffering from dysmenorrhea were studied in relation to concomitant hormone levels in blood (progesterone, hGH, prolactin, cortisol, vasopressin, and 15‐keto‐13, 14‐dihydro‐PGF 2α ). In the four normal women uterine activity decreased after midnight, unrelated to circulating levels of 15‐keto‐13,14‐dihydro‐PGF 2α . But during a dysmenorrheic episode the uterine hyper‐contractility pattern correlated well with levels of the PGF 2α ‐metabolite, indicating a role of endogenous‐produced PGF 2α in this condition. The results demonstrate a diurnal rhythm, possibly related to the wake‐sleep cycle. No simple associations were seen between vasopressin, cortisol, prolactin, hGH, the PGF 2α ‐metabolite, and uterine activity.