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The fetal renin‐angiotensin system in pregnancy‐induced hypertension
Author(s) -
SYMONDS E. M.,
LAMMING G.D.,
CRAVEN D.J.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb05270.x
Subject(s) - plasma renin activity , medicine , renin–angiotensin system , cord blood , fetus , pregnancy , venous blood , proteinuria , blood pressure , vein , obstetrics , endocrinology , kidney , biology , genetics
Summary. Maternal and fetal blood samples were obtained from 10 normotensive primigravidae and 10 primigravidae with pregnancies complicated by hypertension and proteinuria. Measurements were performed of plasma renin activity (PRA), plasma renin concentration (PRC) and plasma renin substrate (PRS). PRA and PRC were significantly higher in cord artery and cord vein blood than in maternal venous blood in normotensive women, and PRS was significantly lower. PRS levels were lower in maternal plasma of hypertensive women and, although PRC and PRA were lower in the cord blood of infants born to hypertensive women, these differences did not achieve statistical significance.