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Placental protein measurements in complicated pregnancies. III. Premature labour
Author(s) -
WESTERGAARD J. G.,
TEISNER B.,
HAU J.,
GRUDZINSKAS J. G.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb04742.x
Subject(s) - gestation , human placental lactogen , pregnancy , placental lactogen , pregnancy associated plasma protein a , premature labor , medicine , obstetrics , blood proteins , predictive value , second trimester , endocrinology , first trimester , fetus , placenta , biology , genetics
Summary. Maternal serum levels of pregnancy‐associated plasma protein‐A (PAPP‐A), human placental lactogen (hPL) and schwangerschafts‐protein 1 (SP1) were measured serially during second and third trimester in 753 women with a normal pregnancy when they were recruited to the study. In 24 women spontaneous premature labour occurred before 37 completed weeks and these women had significantly lower mean levels of serum SP1 at 29–31 weeks and at 33–34 weeks gestation but similar mean levels of serum PAPP‐A and hPL at all gestations compared with corresponding values in normal pregnancy. The predictive value of an abnormal SP1 result was 5.2% at 29–31 weeks and 10.3% at 33–34 weeks. Furthermore, trends of levels of the three placental proteins in individual patients were similar to those seen in normal pregnancy, and the trends were unrelated to the occurrence of other complications and the time of onset of labour. This study suggests that measurements of the three placental proteins are unlikely to be of any value in the prediction of spontaneous premature labour.