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Absence of prolactin receptors in normal and malignant uterine cervix
Author(s) -
DOWSETT M.,
McGARRICK G. E.,
STAFFURTH J.,
WORTH R. W.,
CHAPMAN M. G.,
JEFFCOATE S. L.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb03710.x
Subject(s) - bromocriptine , prolactin , receptor , cervix , medicine , cervical cancer , uterine cervix , endocrinology , cancer , cancer research , oncology , carcinoma , hormone
Summary. Bromocriptine has been found to be an effective agent in the treatment of advanced cancer of the uterine cervix, and it was thus possible that the tumours were prolactin‐dependent. A prolactin receptor assay was established and validated, but no receptors were found in cervical tissue whether normal or with benign or malignant disease. It is unlikely that cervical tumours are prolactin‐dependent.