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The influence of spontaneous and induced labour on the rise in prostaglandins at amniotomy
Author(s) -
SELLERS S. M.,
MITCHELL M. D.,
ANDERSON A. B. M.,
TURNBULL A. C.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb03695.x
Subject(s) - prostaglandin , pessary , prostaglandin e , medicine , pregnancy , endocrinology , prostaglandin f , prostaglandin e2 , prostaglandin e1 , obstetrics , biology , genetics
Summary. Maternal peripheral plasma levels of 13, 14‐dihydro‐15‐keto‐prostaglandin F (PGFM) were measured immediately before and 5 min after amniotomy. Three groups of women were studied: women in late pregnancy; women in spontaneous labour; and women who had received intravaginal prostaglandin E 2 (PGE 2 ) pessary. There was no significant difference in the magnitude of the rise in PGFM after amniotomy in late pregnancy or during spontaneous labour suggesting that labour has no influence on the release of prostaglandin F 2α (PGF 2α ) induced by artificial rupture of the fetal membranes. However, local administration of PGE 2 before amniotomy caused a greater rise in PGFM suggesting that PGE 2 can influence the release and/or metabolism of PGF 2α .