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The value of immunohistochemical markers in the diagnosis of cervical neoplasia
Author(s) -
FRAY R. E.,
HUSAIN O. A. N.,
TO A. C. W.,
WATTS K. C.,
LADER S.,
ROGERS G. T.,
TAYLORPAPADIMITRIOU J.,
MORRIS N. F.
Publication year - 1984
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1984.tb03684.x
Subject(s) - immunohistochemistry , value (mathematics) , pathology , medicine , mathematics , statistics
Summary. This study was designed to determine whether immunohistochemical stains for tumour‐associated markers may be useful in the detection and differential diagnosis of premalignant and malignant lesions of the cervix. The expression of four markers detected by monoclonal antibodies, human milk fat globule 1 and 2 (HMFG‐1 and 2), Cal and anti‐carcinoembryonic antigen (anti‐CEA) on conventional histological sections of various cervical lesions has been investigated. None of these markers was specific for neoplastic lesions of the cervix and all four markers were expressed by metaplastic as well as neoplastic cells, and it was concluded that their application in the histopathological examination of the cervix is limited.