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Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea
Author(s) -
ME V.,
EDWARDS R. LOGAN,
LYNCH S. S.,
BUTT W. R.
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08964.x
Subject(s) - luteinizing hormone , hormone , medicine , endocrinology , stimulation , ovary , hormone receptor , cancer , breast cancer
Summary. The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome). After an initial phase of stimulation, there was a uniform and sustained suppression of gonadotrophin concentrations in all the patients during the 20–24 days of treatment, presumably due to down‐regulation of the pituitary receptors. One patient ovulated after stopping treatment.