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Metabolic inactivation of noradrenaline in human placenta, umbilical cord and fetal membranes
Author(s) -
SAARIKOSKI SEPPO
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08960.x
Subject(s) - umbilical cord , placenta , monoamine oxidase , fetus , catechol o methyl transferase , wharton's jelly , membrane , fetal membrane , andrology , chemistry , biochemistry , pregnancy , enzyme , biology , medicine , anatomy , genetics , allele , gene
Summary. Metabolic inactivation of noradrenaline (NA) was studied in human placenta, umbilical vessels, Wharton's jelly and fetal membranes. Highest degradation capacity was observed in the placenta and fetal membranes, where the NA was inactivated by both monoamine oxidase (MAO) and catechol‐O‐methyltransferase (COMT). No MAO and COMT activity was found in the cord jelly and the activities in umbilical vessels were very low.