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Prognostic significance of herpes simplex virus antibody status in women with cervical intraepithelial neoplasia (CIN)
Author(s) -
COLEMAN D. V.,
MORSE A. R.,
BECKWITH P.,
ANDERSON M. C.,
GARDNER S. D.,
KNOWLES W. A.,
SKINNER G. R. B.
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08937.x
Subject(s) - herpes simplex virus , cervical intraepithelial neoplasia , medicine , cytomegalovirus , serology , antibody , lesion , squamous intraepithelial lesion , gynecology , gastroenterology , virus , herpesviridae , pathology , viral disease , immunology , cervical cancer , cancer
Summary. A total of 107 women with abnormal cervical smears showing cytological changes consistent with cervical intraepithelial neoplasia (CIN) 1 or CIN 2 were kept under regular cytological, colposcopic, virological and serological surveillance for an average of 18 months (range 9 months‐3 years). Regression of the cervical lesion was noted in 31 (29%) and progression to CIN 3 in nine women (8.4%). We found a positive correlation between the presence of type 2 antibody and progression of CIN 1 and 2 to CIN 3 and a negative association with the presence of type 1 antibody and suggest the antibody status of a woman with CIN 1 or CIN 2 may provide a useful basis for follow‐up. We found no association between the outcome of the cervical lesion and active infection with herpes simplex or cytomegalovirus or any other infectious agent or sex‐related factors.