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Complex formation of pregnancy‐specific α 2 –glycoprotein (SP 1 α) and heparin
Author(s) -
AHMED A. G.,
KLOPPER A.
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08915.x
Subject(s) - heparin , oxalate , chemistry , immunoelectrophoresis , heparin sodium , glycoprotein , sodium citrate , chromatography , sodium , biochemistry , medicine , inorganic chemistry , immunology , antibody , organic chemistry , pathology
Summary. The Schwangerschaftsprotein 1 (SP 1 ,)α values in blood measured by rocket immunoelectrophoresis are affected by the addition of anticoagulants. When compared with values in serum, those in heparin plasma were much higher, while those in sequestrene ethylenediaminetetra acetic acid), sodium citrate and fluoride oxalate were lower. On the other hand, SP 1 and SP 1 β concentrations were not significantly affected in heparin or sequestrene and were only slightly depressed in sodium citrate and flouride oxalate. The effect of heparin on SP 1 α in serum was dosedependent. We surmise that SP 1 α forms a complex with heparin and that it may be involved in the coagulation system in pregnancy.