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Serum protein pattern in normal pregnancy with special reference to acute‐phase reactants
Author(s) -
HARAM KJELL,
AUGENSEN KÅRE,
ELSAYED SAID
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08898.x
Subject(s) - haptoglobin , orosomucoid , acute phase protein , pregnancy , gestation , medicine , globulin , blood proteins , ceruloplasmin , third trimester , albumin , endocrinology , c reactive protein , first trimester , glycoprotein , biochemistry , biology , inflammation , genetics
Summary. The concentrations of acute‐phase protein reactants, total protein, albumin and globulin fractions were measured throughout normal pregnancy in 27 women. α 1 ‐Antitrypsin and caeruloplasmin concentrations increased gradually to reach their highest levels in the third trimester. Orosomucoid and haptoglobin showed similar patterns: higher levels in the first and third trimester with a decline around 24 weeks gestation. C‐Reactive protein showed levels similar to those of non‐pregnant healthy individuals (< 5 mg/1) throughout pregnancy. α 1 ,‐, α 2 and β‐Globulin concentrations increased from the first trimester towards term. γ‐Globulin concentration changed little during gestation. The data obtained provide reference ranges for serum proteins in healthy pregnancy.