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Effect of vacuum curettage on the concentrations of plasma 6‐keto‐prostaglandin F lα and serum thromboxane B 2
Author(s) -
YLIKORKALA O.,
MÄKILÄ U.M.,
VIINIKKA L.
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb08619.x
Subject(s) - prostacyclin , thromboxane a2 , myometrium , prostaglandin , thromboxane b2 , thromboxane , endocrinology , medicine , curettage , chemistry , alpha (finance) , placenta , cervix , ergometrine , in vivo , prostanoid , uterus , pregnancy , platelet , fetus , biology , surgery , construct validity , genetics , cancer , patient satisfaction , microbiology and biotechnology
Summary. Serial plasma samples collected before and after vacuum curettage followed by methylergometrine injection in 10 women were assayed for 6‐keto‐prostaglandin F lα (6‐keto‐PGF 1α ). The mean 6‐keto‐PGF lα concentration was 97.2 (SE 8.8) pg/ml before cervical dilatation. The concentration rose to 128.2 (SE 13.5) pg/ml (P < 0.10) immediately and to 133.3 (SE 17.8) pg/ml (P < 0.05) 1 h after curettage and returned to the initial value within 5 h. Neither methylergometrine nor anaesthesia, nor non‐gynaecological surgery, caused changes in the level of plasma 6‐keto‐PGF lα . The capacity of the platelets to produce thromboxane A 2 during spontaneous clotting of blood did not change during vacuum curettage, anaesthesia and non‐gynaecological surgery, nor after methylergometrine. The evidence suggests that the pregnant myometrium and/or intrauterine tissues capable of generating prostacyclin (PGI 2 ) in vitro may release PG1 2 also in vivo .