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The influence of oral contraceptives on activated factor X inhibitor (XaI)‐activity: a prospective study
Author(s) -
BERGQVIST A.,
BERGQVIST D.,
TANGEN O.
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb06769.x
Subject(s) - levonorgestrel , medicine , pill , prospective cohort study , gynecology , population , family planning , research methodology , pharmacology , environmental health
Summary. A prospective study of activated factor X inhibitor (XaI) activity has been performed in women randomly allocated to contraceptive pills containing 30μg+150μg (63 women) or 50μg+250μg (44 women) ethinyl oestradiol and levonorgestrel, and a reference group of 35 women using other contraceptive methods. The XaI‐activity was measured six times during 1 year of observation. There was a significant reduction of XaI‐activity after 1 month of oestrogen consumption but there was no significant difference between 30 and 50 μg users. The maximal reduction during the observation period was 12% in both groups. There was positive correlation between the pretreatment value and the maximal reduction in the same patient, but the activity did not fall below the normal range (75–125% of normal human plasma).