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Comparison between antifibrinolytic and antiprostaglandin treatment in the reduction of increased menstrual blood loss in women with intrauterine contraceptive devices
Author(s) -
YLIKORKALA OLAVI,
VIINIKKA LASSE
Publication year - 1983
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1983.tb06751.x
Subject(s) - medicine , tranexamic acid , menstruation , antifibrinolytic , fibrinolysis , placebo , blood loss , anemia , gynecology , surgery , alternative medicine , pathology
Summary. The effects of a fibrinolysis inhibitor (tranexamic acid, TA) and prostaglandin synthesis inhibitor (diclofenac sodium, DS) were compared in the reduction of excessive menstrual blood loss in 19 women with an intrauterine contraceptive device (IUCD). These women (mean blood loss before treatment to 135.1±18.9 SE ml, range 70–294 ml) were treated in random order with TA (1.5 g three times daily for 5 days starting on the first day of menstruation for two periods), and with DS (50 mg three times on the first day followed by 25 mg three times daily for 4 days, for two periods), or with placebo (one period) in a double‐blind trial. The placebo treatment did not change menstrual blood loss (128.3±15.6 ml). The TA treatment decreased blood loss to 59.4±7.7 ml ( P <0.001) and the DS treatment to 102.1±13.6 ml ( P <0.01). Neither treatment abolished pelvic discomfort during menstruation or shortened its duration. Various side‐effects were noted by 12 women during 19 TA treatments and by five women during six DS treatments. Thus, while TA is generally far more effective, DS gave pronounced decreases in menstrual bleeding in some women and had less frequent side‐effects.