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Tissue and plasma concentrations of pregnancy‐associated plasma protein‐A (PAPP‐A): comparison with other fetoplacental products
Author(s) -
DUBERG S.,
BISCHOF P.,
SCHINDLER A. M.,
BÉGUIN F.,
HERRMANN W.,
SIZONENKO P. C.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb05077.x
Subject(s) - decidua , radioimmunoassay , trophoblast , human placental lactogen , prolactin , endocrinology , medicine , placental lactogen , microgram , andrology , pregnancy associated plasma protein a , gestation , amniotic fluid , placenta , chemistry , pregnancy , amnion , biology , hormone , fetus , biochemistry , genetics , first trimester , in vitro
Summary. Human placental lactogen (hPL), α‐fetoprotein (AFP), prolactin (PRL) and pregnancy‐associated plasma protein‐A (PAPP‐A) were measured by radioimmunoassay in plasma, in homogenates of trophoblast, decidua, chorion, amnion and in amniotic fluid from 10 patients after non‐complicated term delivery. Plasma samples and homogenates of trophoblast and decidua were also collected from 10 patients undergoing surgical termination of pregnancy between 7 and 12 weeks gestation. In addition, plasma and endometrial samples from 10 patients undergoing hysterectomy for other indications than malignancy were analysed for comparison. The highest tissue concentrations of hPL, AFP and PRL corresponded in each case to the known site of synthesis. For PAPP‐A the highest concentration was found in maternal plasma at term [238·8±75·6 (SEM)μg/ml]. The highest tissue concentration was found at term in the decidua (57·0±2·0 μg/g), more than three times higher than that in the trophoblast (16·9±5·4 μg/g). The concentrations of PAPP‐A in endometrial samples from non‐pregnant women (1·9±0·6 μg/g) was 40 times higher than that in the corresponding plasma samples (0·05±0·02 μg/ml). These observations point to the decidua as a possible source of PAPP‐A.