Premium
Production of active and inactive renin by cultured explants from the human female genital tract
Author(s) -
WARREN A. Y.,
CRAVEN D. J.,
SYMONDS E. M.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04717.x
Subject(s) - decidua , myometrium , amnion , hysterotomy , andrology , cervix , uterus , explant culture , biology , medicine , endocrinology , pregnancy , placenta , in vitro , fetus , genetics , cancer , biochemistry
Summary. Myometrium, decidua, chorio‐decidua and amnion were collected from women undergoing caesarean section and from pregnant women at hysterectomy and hysterotomy for comparison with myometrium, cervix and endometrium taken from non‐pregnant women at hysterectomy. Homogenates of chorio‐decidua and amnion contained the largest concentrations of active and inactive renin. Cultured explants of all tissues except amnion were found to produce both types of renin. The percentage of active renin produced before 20 days of culture was significantly greater in cultures of chorio‐decidua than in those of myometrium (P < 0,0005) or decidua Vera (P< 0.029, which suggests that renin synthesis in vivo is probably confined to the chorio‐decidua.