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Plasma prostanoids in pregnancy‐induced hypertension
Author(s) -
KOULLAPIS E. N.,
NICOLAIDES K. H.,
COLLINS W. P.,
RODECK C. H.,
CAMPBELL S.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04715.x
Subject(s) - medicine , radioimmunoassay , thromboxane b2 , alpha (finance) , pregnancy , prostaglandin , endocrinology , metabolite , gestational age , obstetrics , gynecology , surgery , platelet , biology , construct validity , genetics , patient satisfaction
Summary. The concentrations of 13,14‐dihydro‐15‐oxo‐prostaglandin F 2α (PGFM), 6‐oxo‐prostaglandin F1 α , a (6‐oxo‐PGF1 α ) and thromboxane B 2 (T×B 2 ) were measured by radioimmunoassay in peripheral plasma from 183 pregnant women attending routine antenatal clinics. A total of 141 patients (47 nulliparous, 94 parous) remained normotensive and had uncomplicated pregnancies. The results from this group showed that there was no significant difference in the concentration of any metabolite in relation to parity or gestational age. The concentrations (pmol/1; means±SD) were PGFM 373±105, 6‐oxo‐PGF 1α 391±104 and T×B 2 373±121. Nineteen patients (12 nulliparous, 7 parous) who had pregnancy‐induced hypertension (PIH) by the time of sampling (three) or who subsequently developed the symptom (mean time from sampling to diagnosis 11 weeks, range 1–24 weeks) had significantly higher levels of 6‐oxo‐PGF lα (574±216; P<0.0005, Student's test) and T×B 2 (603±268; P <0.0005). The concentrations in seven nulliparous patients with PIH and proteinuria were 656±276 for 6‐oxo‐PGF 3α and 754±228 pmol/1 for T×B 2 .