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Inhibition of prostaglandin synthase by maternal plasma factor(s) in early human pregnancy
Author(s) -
BRENNECKE S. P.,
LENTON E. A.,
TURNBULL A. C.,
MITCHELL M. D.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04714.x
Subject(s) - prostaglandin , radioimmunoassay , endocrinology , medicine , conceptus , incubation , pregnancy , chemistry , decidual cells , early pregnancy factor , atp synthase , enzyme , biology , gestation , fetus , biochemistry , placenta , genetics
Summary. Using an enzyme incubation‐radioimmunoassay technique, we have tested the hypothesis that an increase in a maternal plasma factor(s) that inhibits prostaglandin synthase (EC 1.14.99.1) is responsible for the suppression of decidual prostaglandin production that occurs in early human pregnancy. Measurements made on serial maternal samples failed to reveal any significant increase in plasma inhibitory activity at this time, and it was concluded that the conceptus achieves the reduction in prostaglandin synthesis by a mechanism other than a systemically mediated direct inhibition of decidual prostaglandin synthase.