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Activity of serum cytidine deaminase during pregnancy
Author(s) -
JONES D. D.,
BAHIJRI S.,
ROBERTS E. L.,
WILLIAMS G. F.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04703.x
Subject(s) - cytidine deaminase , cytidine , enzyme , activation induced (cytidine) deaminase , pregnancy , adenosine deaminase , chemistry , amp deaminase , biochemistry , biology , immunology , antibody , genetics , immunoglobulin class switching , b cell
Summary. A simple and reliable method for the estimation of cytidine deaminase (cytidine aminohydrolase; EC 3.5.4.5) activity in pregnancy serum is described. This enzyme does not require magnesium for activation and is also more stable than deoxycytidylate deaminase (dCMP deaminase, dCMP aminohydrolase; EC 3.5.4.12). There was excellent correlation between the two enzymes ( r = 0.92). Both enzymes showed increased activity in abnormal pregnancy. Both enzyme activities were found to be similar in 1305 maternal serum samples and therefore due to the simplicity of cytidine deaminase estimation it is recommended for the screening of large numbers of antenatal sera for abnormal pregnancies.