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Elevated intravesicular fluid luteinizing hormone concentration in hydatidiform mole
Author(s) -
GUNASEGARAM R.,
PEH K. L.,
LOGANATH A.,
KARIM S. M. M.,
RATNAM S. S.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04685.x
Subject(s) - luteinizing hormone , endocrinology , prolactin , medicine , radioimmunoassay , hormone , follicle stimulating hormone , chemistry , mole , biology
Summary. Concentrations of human chorionic gonadotrophin (β‐hCG), follicle‐stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) were measured by radioimmunoassay in the serous fluid of hydatid vesicles obtained from 27 patients with hydatidiform mole. High amounts of all four hormones were found in every case. The mean concentrations ± SEM were 710.8 ± 100.8 i.u./l×10 −3 for β‐hCG, 13.8 ± 0.3 i.u./l for FSH, 302.2 ± 34.5 i.u./l×10 −3 for LH and 2610.8 ± 562.1 m‐i.u./l for PRL. It is suggested that aberrations in the mechanisms controlling the synthesis and release of luteinizing hormone‐releasing factor (LH‐RF) could result in chronically elevated LH levels leading to changes characteristic of this disease.