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Down‐regulation of gonadotrophin secretion in postmenopausal women by a superactive LHRH analogue: lack of effect on menopausal flushing
Author(s) -
LIGHTMAN STAFFORD L.,
JACOBS HOWARD S.,
MAGUIRE ANITA K.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04649.x
Subject(s) - flushing , endocrinology , climacteric , medicine , pulsatile flow , postmenopausal women , secretion , plasma levels , menopause
Summary. The effect of the LHRH analogue D‐Ser (TBU) 6 ‐EA 10 ‐LRH (Hoe 766) on the response of plasma gonadotrophins and the frequency of climacteric flushing was studied in five postmenopausal women. Following an initial stimulatory effect on gonadotrophin secretion plasma gondotrophins returned to near baseline concentrations with loss of their pattern of pulsatile release and of their sensitivity to exogenous LHRH. The frequency of flushing was unaltered during the treatment period.