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Circulating antithrombins in pregnancy
Author(s) -
TEISNER B.,
DAVEY MARY W.,
GRUDZINSKAS J. G.
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb04637.x
Subject(s) - antithrombins , antithrombin , pregnancy , alpha (finance) , alpha 2 macroglobulin , medicine , endocrinology , macroglobulin , chemistry , obstetrics , biology , surgery , heparin , construct validity , patient satisfaction , genetics
Summary. In a cross‐sectional study circulating levels of antithrombins, antithrombin III 1 α‐antitrypsin and α 2 ‐macroglobulin were measured in groups of 20 women before pregnancy, during each trimester and post partum . Blood levels of antithrombin III were signicantly lower, α 1 antitrypsin higher and %aL 2 ‐macroglobulin no different when compared with those of the non‐pregnant and puerperal states. These findings suggest that there may be not only an increase in total antithrombin production, but also a qualitative change in antithrombin‘activity’, the principal protein during pregnancy being α 1 ‐antitrypsin.