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Evidence for an association between Chlamydia trachomatis and cervical intraepithelial neoplasia
Author(s) -
HARE M. J.,
TAYLORROBINSON D.,
COOPER PAULINE
Publication year - 1982
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1982.tb03643.x
Subject(s) - chlamydia trachomatis , cervical intraepithelial neoplasia , ureaplasma urealyticum , mycoplasma hominis , cervix , gynecology , medicine , colposcopy , cervical cancer , chlamydia , hysterectomy , mycoplasma , cancer , pathology , biology , immunology , microbiology and biotechnology
Summary. Attempts were made to isolate Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum from women with cervical intraepithelial neoplasia (CIN), from those with microinvasive or invasive cervical cancer, and from a control group of similar women with other gynaecological problems. C. trachomatis was found in a significantly greater proportion of women with CIN (8%) or cervical cancer (18%) than in the control group (1%), whereas M. hominis and U. urealyticum were approximately as common in each group. Histological examination of the cervix in cone biopsies or hysterectomy specimens from 26 women with CIN and from 39 women of similar age with no evidence of CIN showed lymphoid follicles, previously reported to be associated with chlamydial infection, in nine of the specimens with CIN, but in none of the specimens without CIN.