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GONADAL DYSGENESIS AND X CHROMOSOME DELETION
Author(s) -
Dewhurst John
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb02234.x
Subject(s) - isochromosome , gonadal dysgenesis , long arm , centromere , genetics , chromosome , short stature , biology , dysgenesis , dicentric chromosome , gene , karyotype , anatomy , endocrinology
Summary Three cases of gonadal dysgenesis associated with deletion of the long arm of the X chromosome and one associated with an isochromosome for the long arm are here described. Their features support the proposition that genes concerned with ovarian differentiation are located in the region of the centromere. The long arm of the X chromosome may, nonetheless, contain some statural determinants whilst loss of all the short arm material may occasionally be associated with normal stature.