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CLIMACTERIC FLUSHING: CLINICAL AND ENDOCRINE RESPONSE TO INFUSION OF NALOXONE
Author(s) -
Lightman S. L.,
Jacobs H. S.,
Maguire A. K.,
McGarrick G.,
Jeffcoate S. L.
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb02229.x
Subject(s) - prolactin , endocrinology , luteinizing hormone , medicine , climacteric , (+) naloxone , endocrine system , hormone , follicle stimulating hormone , flushing , saline , opioid , menopause , receptor
Summary Six postmenopausal women with frequent attacks of flushing were studied by measuring plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin and noradrenaline concentrations at regular and frequent intervals and at the time of each of 82 flushes. The hormone measurements were made on a control day and on the second day during infusion of either naloxone (22 μ g/min) or saline. The perception of a flush was associated with a significant increase of plasma LH concentrations. There were no significant changes in plasma FSH, prolactin or noradrenaline concentrations. Naloxone infusion resulted in a highly significant reduction in the frequency of flushes and in the number of LH pulses. We conclude that flushing and its neuro‐endocrine correlates are related to activation of opiate receptors. Naloxone may provide the basis for a non‐steroidal treatment of climacteric flushing attacks.