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HAEMOGLOBIN AIc PREDICTS THE PERINATAL OUTCOME IN INSULIN‐DEPENDENT DIABETIC PREGNANCIES
Author(s) -
Ylinen K.,
Raivio K.,
Teramo K.
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb01681.x
Subject(s) - medicine , pregnancy , fetus , obstetrics , diabetes mellitus , insulin , third trimester , perinatal mortality , metabolic control analysis , endocrinology , biology , genetics
Summary Haemoglobin A Ic (Hb A Ic ) was measured in 112 insulin‐dependent diabetic pregnancies on an average 4.7 times. Hb A Ic was high in early pregnancy in all three patients with severe fetal malformations. There were six pregnancies with a perinatal death. The maximum Hb A Ic values were significantly higher in the second trimester (p <0.001) in these pregnancies than in the other diabetic pregnancies. When neonatal hypoglycaemia was present, the mean maternal Hb A I c was significantly higher in the second (p <0.005) and third (p <0.02) trimesters of pregnancy than in the group without neonatal hypoglycaemia. In the group with neonatal hyperbilirubinaemia the mean maternal Hb A Ic was significantly higher in the third trimester (p <0.02) than in the group with no neonatal hyperbilirubinaemia. The results suggest that poor metabolic control of maternal diabetes during the second trimester is associated with a clearly increased risk of perinatal death and during the second and third trimesters with metabolic derangements in the neonatal period. The results also indicate that Hb A Ic could be used to detect the pregnant diabetics at special risk.