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FACTOR VIII COMPLEX IN NORMAL PREGNANCY, PRE‐ECLAMPSIA AND FETAL GROWTH RETARDATION
Author(s) -
Fournie A.,
Monrozies M.,
Pontonnier G.,
Boneu B.,
Blerme R.
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb00977.x
Subject(s) - eclampsia , growth retardation , fetal growth , fetus , pregnancy , medicine , obstetrics , biology , genetics
Summary The levels of the three components of factor VIII complex (VIII R:AG, VIII R:WF, VIII :C) were measured during normal late pregnancy, in pre‐eclampsia and in pregnancies complicated by fetal growth retardation. In late normal pregnancy, there was a steady increase in factor VIII complex and the highest level was reached at delivery; in primary fetal growth retardation, the values were similar. In pregnancies complicated by pre‐eclampsia, with or without fetal growth retardation, there was a significant increase of VIII R: AG VIII R: WF; the more severe the course of the disease, the greater the increase. The level of VIII R: AG—VIII R: WF appears to be an indicator of vascular pathology and it is suggested that this assessment may be of value in monitoring high risk pregnancies.