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PRIMARY HYPOTHYROIDISM AND OVARIAN ACTIVITY EVIDENCE FOR AN OVERLAP IN THE SYNTHESIS OF PITUITARY GLYCOPROTEINS
Author(s) -
Evers J. L. H.,
Rolland R.
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb00967.x
Subject(s) - luteinizing hormone , medicine , endocrinology , prolactin , hormone , thyroid , secondary sex characteristic , thyroid function , ovary
Summary A 14‐year‐old girl presented with precocious sexual development, galactorrhoea and symptoms and signs suggestive of hypothyroidism. On physical examination a tumour was found in the lower abdomen. Serum gonadotrophins, especially luteinizing hormone, serum thyroid stimulating hormone and prolactin were elevated. Measurement of thyroid hormones and additional thyroid function tests confirmed the diagnosis of primary hypothyroidism. Ultrasound investigation revealed the mass in the lower abdomen to be of a cystic nature and to originate from the right ovary. Following the institution of thyroid substitution therapy, all symptoms disappeared, biochemical and hormonal abnormalities returned to normal and the ovarian size decreased to normal. A hypothesis is presented for non‐specific pituitary glycoprotein hormone synthesis secondary to the hypothyroidism, as the cause of the syndrome.