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SERIAL CHANGES IN RENAL HAEMODYNAMICS DURING NORMAL HUMAN PREGNANCY
Author(s) -
Dunlop W.
Publication year - 1981
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1981.tb00929.x
Subject(s) - effective renal plasma flow , pregnancy , renal function , medicine , filtration fraction , third trimester , obstetrics , renal blood flow , first trimester , gestation , biology , genetics
Summary Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were determined at constant intervals during and after the normal pregnancies in 25 healthy women. Compared with non‐pregnant values, ERPF increased by 80 per cent during early pregnancy but fell significantly from this new level during the third trimester. GFR, however, remained at a level 50 per cent above the non‐pregnant throughout pregnancy. Filtration fraction (GFR/ERPF) was significantly reduced during early pregnancy but rose to a value equivalent to the non‐pregnant during the third trimester. Comparable data of previous workers are re‐interpreted.