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MATERNAL PLASMA ANDROGENS IN EARLY HUMAN PREGNANCY
Author(s) -
Harrison R. F.,
Mansfield M. D.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04603.x
Subject(s) - androstenedione , testosterone (patch) , gestation , endocrinology , medicine , dihydrotestosterone , pregnancy , hormone , fetus , androgen , biology , genetics
Summary Mean maternal plasma levels of testosterone, androstenedione, and 5 α‐dihydro‐testosterone were established from 4 to 16 weeks gestation from twice‐weekly blood samples taken from 15 pregnant women. All three hormone levels were raised when compared with the non‐pregnant state. There were significant differences in mean maternal plasma testosterone levels at 4 to 5 and 7 to 8 weeks gestation, when comparing women carrying male and female fetuses. Androstenedione levels in a twin pregnancy were increased throughout and testosterone levels were more than 1 SD above the mean from week 15. Steroid levels fell late in the two women who aborted. Hormone levels in three women being given progestogens were within normal limits.