Premium
PLASMA PROSTAGLANDIN CONCENTRATIONS AFTER CERCLAGE IN EARLY PREGNANCY
Author(s) -
Toplis P. J.,
Shepherdj J. H.,
Youssefmejadian E.,
Jakubowicz Diana,
Dewhurst John
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04599.x
Subject(s) - medicine , pregnancy , cervical cerclage , salbutamol , prostaglandin , oxytocin , cervical dilatation , prostaglandin f , anesthesia , obstetrics , gestation , gynecology , cervix , genetics , asthma , biology , cancer
Summary A prospective, randomized controlled study was made to measure the circulating levels of 13, 14‐dihydro‐15‐keto‐prostaglandin F (PGFM) in two groups of women having cervical cerclage early in the second trimester of pregnancy. One group of patients was given omnopon by intramuscular injection for 24 hours after operation and the other salbutamol by intravenous infusion. A significant rise in circulating PGFM was found in both groups after cervical cerclage and the magnitude of the rise was similar in the two groups; levels of PGFM in both groups had returned to the preoperative levels within 24 hours of operation. The levels of PGFM before and after operation showed no relation to the eventual outcome of the pregnancy, which was successful in 80 per cent of patients.