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THE USE OF PROSTAGLANDIN E 1 ANALOGUE PESSARIES IN PATIENTS HAVING FIRST TRIMESTER INDUCED ABORTIONS
Author(s) -
Nakano R.,
Hata H.,
Sasaki K.,
Yamoto M.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04541.x
Subject(s) - medicine , cervix , pessary , vacuum aspiration , abortion , pregnancy , cervical dilatation , products of conception , obstetrics , prostaglandin , prostaglandin e1 , gynecology , population , research methodology , family planning , environmental health , cancer , biology , genetics
Summary A new prostaglandin analogue, 16, 16‐dimethyl‐trans‐Δ 2 ‐PGE 1 methyl ester (16 me E 1 ) was used for preoperative cervical dilatation in 23 pregnant women who had abortion induced for socio‐economical reasons in the first trimester of pregnancy. A single vaginal pessary containing 1 mg 16 me E 1 was inserted into the posterior fornix at 3‐hour intervals. Thirteen (56.5 per cent) of the 23 patients had complete abortions and two patients (8.7 per cent) had incomplete abortions. In six patients (26.1 per cent) the cervix was dilated to at least 10 mm and the remaining two patients (8.7 per cent) required mechanical dilatation at the time of vacuum evacuation. Apart from mild gastrointestinal symptoms, no serious side effects were noted. It is concluded that the new prostaglandin analogue, 16 me E 1 , could be used safely and effectively for preoperative dilatation of the cervix before surgical abortion in early pregnancy.