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THE IN VITRO PRODUCTION OF PROSTANOIDS BY THE HUMAN CERVIX DURING PREGNANCY: PRELIMINARY OBSERVATIONS
Author(s) -
Ellwood D. A.,
Mitchell M. D.,
Anderson Anne B. M.,
Turnbull A. C.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04520.x
Subject(s) - cervix , prostanoid , thromboxane b2 , pregnancy , prostaglandin , medicine , prostaglandin f , hysterectomy , alpha (finance) , obstetrics , andrology , prostaglandins f , gynecology , endocrinology , biology , surgery , platelet , construct validity , patient satisfaction , cancer , genetics
Summary The ability of the pregnant human cervix to produce prostanoids has been studied using an in vitro superfusion technique. Tissues obtained from four patients during the first trimester of pregnancy produced prostaglandin E (PGE), prostaglandin F (PGF), 13,14‐dihydro‐15‐oxo‐prostaglandin F (PGFM) and 6‐oxo‐prostaglandin F 2α (6‐oxo‐PGF 1α ). Production of thromboxane B 2 (TXB 2 ) was minimal. Preliminary studies using tissue taken at Caesarean hysterectomy during the last trimester of pregnancy indicate that the cervix may show increased prostanoid production during active dilatation. The implications of these observations for an involvement of prostanoids in cervical softening during human parturition are discussed.