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PLASMA PROSTAGLANDIN F LEVELS AND MALIGNANT TUMOURS OF THE FEMALE GENITAL TRACT
Author(s) -
Sanders R. R.,
Lee W. H.,
Koh L.,
Brennecke A.,
Jones W. R.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04507.x
Subject(s) - malignancy , radioimmunoassay , medicine , prostaglandin , female circumcision , genital tract , stage (stratigraphy) , gastroenterology , pathology , urology , endocrinology , gynecology , physiology , biology , paleontology
Summary Plasma prostaglandin F (PGF) was measured by a radioimmunoassay method in 24 subjects with tumours of the female genital tract. Levels in the tumour group ranged from 25 pg/ml to 134 pg/ml and were almost all greater than the values observed in a control group of 41 healthy women who had a mean (±SD) level of 21 (±3.4) pg/ml. There was a relationship between plasma PGF levels and the stage of the disease. Patients with resectable tumours showed a fall in PGF levels postoperatively and those with disseminated malignancy demonstrated increasing levels as the disease progressed. Plasma PGF may provide a clinical prognostic marker in the management of patients with malignant tumours.