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DIURNAL CHANGES IN MATERNAL PLASMA OESTRONE AND OESTRADIOL AT 30 TO 31, 34 TO 35 AND 38 TO 39 WEEKS GESTATIONAL AGE
Author(s) -
Challis J. R. G.,
Patrick J. E.,
Campbell Karen,
Natale R.,
Richardson B.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04462.x
Subject(s) - circadian rhythm , endocrinology , medicine , gestation , blood sampling , pregnancy , diurnal temperature variation , plasma concentration , gestational age , fetus , estriol , hormone , biology , genetics , atmospheric sciences , geology
Summary Diurnal changes in the concentrations of oestrone (E 1 ) and oestradiol (E 2 ) in maternal peripheral plasma have been measured in samples of blood taken at one hour intervals from women at 30 to 31, 34 to 35 and 38 to 39 weeks of pregnancy. There was a significant effect of time of sampling on the plasma concentration of E 1 at all stages of gestation, and circadian changes in the levels of E 1 were apparent at 34 to 35 and 38 to 39 weeks. Peak values were measured around 0830 to 0930 hours, and troughs occurred between 0130 and 0530 hours. Significant effects of time of sampling on the plasma concentration of E 2 were found at 34 to 35 and 38 to 39 weeks of pregnancy; night‐time concentrations were lower than the peak values at 0730 to 0830 hours. The relation of these changes to the circadian rhythms in the concentrations of cortisol and oestriol in maternal plasma are discussed.