Premium
ORIGIN OF AMNIOCENTESIS‐INDUCED RISES OF ALPHA‐FETOPROTEIN CONCENTRATIONS IN MATERNAL SERUM
Author(s) -
Dallaire L.,
Bélanger L.,
Smith Carol J. P.,
Kelleher P. C.
Publication year - 1980
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1980.tb04436.x
Subject(s) - amniocentesis , amniotic fluid , alpha fetoprotein , concanavalin a , alpha (finance) , fetus , fetal protein , agarose , medicine , andrology , pregnancy , obstetrics , endocrinology , prenatal diagnosis , chemistry , chromatography , biology , biochemistry , surgery , genetics , construct validity , patient satisfaction , hepatocellular carcinoma , in vitro
Summary An elevation of alpha‐fetoprotein concentration in maternal serum occurred in 7 of 65 patients (11 per cent) following amniocentesis. Analysis of the molecular heterogeneity of the alpha‐fetoprotein by chromatography on concanavalin A‐agarose indicated that the source of the alpha‐fetoprotein was fetal serum in three patients and amniotic fluid in four patients.