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SERUM GONADOTROPHINS, PROLACTIN AND OVARIAN STEROIDS IN PRIMARY DYSMENORRHOEA
Author(s) -
Ylikorkala O.,
Puolakka J.,
Kauppila A.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10829.x
Subject(s) - prolactin , endocrinology , medicine , menstrual cycle , hormone , ovulation , chemistry
Summary Serum samples were collected from 27 women with incapacitating primary dysmenorrhoea and from 16 normal women in the early part of the cycle (between days 3 to 6), at midcycle (between days 13 to 16) and in the late part of the cycle (between days 23 to 26) for determination of FSH, LH, prolactin (PRL), 17‐ oestradiol (E 2 ) and progesterone (P). The gonadotrophin and P levels showed normal and similar ovulatory patterns in both groups. The PRL concentrations (mean±SD) in dysmenorrhoeic women were lower than normal in the early part (9.2±4.0 ng/ml vs 14.5±7.3 ng/ml, p <0.01) and in late part of the cycle (11.7±5.2 ng/ml vs 16.5±10.2 ng/ml, p 0.05), but not so at midcycle (9.1±2.8 ng/ml vs 10.4±4.4 ng/ml, p> 0.05). The E 2 level was higher than normal in dysmenorrhoeic women in the late cycle (163.0±76.7 pg/ml vs 93.3±64.3 pg/ml, p < 0.01), but apart from this the ratio of E 2 /P did not differ between the groups. These hormonal changes may be related to an excessive production of endometrial prostaglandins in primary dysmenorrhoea.