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PRIMARY DYSMENORRHOEA AND VASOPRESSIN
Author(s) -
ÅKerlund M.,
Strömberg P.,
Forsling M. L.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10794.x
Subject(s) - vasopressin , endocrinology , medicine , menstrual cycle , radioimmunoassay , luteal phase , plasma concentration , plasma osmolality , arginine , chemistry , hormone , amino acid , biochemistry
Summary The circulating concentrations of arginine vasopressin on day 1 and on day 5 to 7 of the menstrual cycle were measured by radioimmunoassay in six women with primary dysmenorrhoea and five controls. All women had ovulated in the previous cycle, as indicated by the mid‐luteal phase plasma progesterone levels and had normal plasma osmolality and sodium concentrations. The plasma concentrations of progesterone and oestradiol on day 1 of the cycle were also measured, and no significant difference between the two groups was seen. In women with dysmenorrhoea the vasopressin concentration on day 1 was 0.400.038 (SE) μU/ml which was significantly higher than the concentration in normal women on the same day of the cycle 0.20±0.063 (SE) μU/ml (p <0.01). The plasma concentration of vasopressin in normal women on day 5 to 7 was 0.68 0.119 (SE) μU/ml which was significantly higher than on day 1 (p <0.01). A significant difference between day 1 and day 5 to 7 was not seen in dysmenorrheic women, possibly because the values were already elevated on day 1. The results suggest that vasopressin could be a factor of aetiological importance in primary dysmenorrhoea, and also indicate that the vasopressin concentration in plasma can vary according to the day of the menstrual cycle.