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THE RELATION BETWEEN PREGNANCY SPECIFIC β1 GLYCOPROTEIN (SP 1 ) LEVELS AND ABNORMAL GLUCOSE TOLERANCE IN PREGNANCY
Author(s) -
Singh M. M.,
Anthony F.,
Wood P. J.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10789.x
Subject(s) - pregnancy , medicine , asymptomatic , endocrinology , impaired glucose tolerance , glucose tolerance test , gestation , diabetes mellitus , type 2 diabetes , biology , insulin resistance , genetics
Summary Pregnancy specific β 1 glycoprotein (SP 1 ) levels were measured in 54 potentially diabetic patients in the third trimester of pregnancy using a laser nephelometric method. All patients were tested by the 50 g oral glucose tolerance test. The results show that a significantly greater number of patients with abnormal glucose tolerance had SP 1 levels above the mean compared with patients with normal glucose responses. All patients with a diabetic type response had SP 1 levels above the mean. There was no significant difference in SP 1 levels in the fasting and two‐hour plasma samples. The study suggests that patients with asymptomatic glucose intolerance in pregnancy have higher SP 1 levels than patients with normal glucose tolerance. It is possible that one of the factors controlling the placental output of SP 1 is the maternal blood glucose level.