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THE RELATION BETWEEN THE CONCENTRATION OF PLACENTAL SPECIFIC PROTEINS IN RETROPLACENTAL AND PERIPHERAL BLOOD
Author(s) -
Grudzinskas J. G.,
Menabawey M.,
Wiley B. A.,
Teisner B.,
Chard T.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10718.x
Subject(s) - medicine , glycoprotein , endocrinology , peripheral , peripheral blood , alpha (finance) , placental lactogen , chemistry , placenta , pregnancy , biology , biochemistry , fetus , surgery , construct validity , patient satisfaction , genetics
Summary Concentrations of four placental proteins: human placental lactogen (hPL), placental protein 5 (PP5), pregnancy specific β 1 glycoprotein (SP 1 ) and human chorionic gonadotrophin (hCG), and a normal serum component, α 2 macroglobulin, were measured in the peripheral circulation and in blood obtained from the retroplacental space in 20 women at term delivery. Levels of hPL and PP5 were higher in the retroplacental blood than in the peripheral circulation in all patients. By contrast, levels of SP 1 and hCG were consistently lower in retroplacental blood than in the peripheral circulation. Similarly, levels of α 2 macroglobulin were lower in the retroplacental blood. It is suggested that this ‘reverse’ gradient is a technical artefact. These findings are discussed in relation to synthesis of placental proteins in a site distal to the retroplacental space, and the introduction of a technical artefact in the collection of samples.