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CIRCULATING LEVELS OF PREGNANCY PROTEINS IN EARLY AND LATE PREGNANCY IN RELATION TO PLACENTAL TISSUE CONCENTRATION
Author(s) -
Lee J. N.,
Grudzinskas J. G.,
Chard T.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10717.x
Subject(s) - pregnancy , andrology , placenta , obstetrics , medicine , biology , fetus , genetics
Summary The concentrations of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), pregnancy specific β 1 glycoprotein (SP 1 ), ferritin (PP2) and placental protein 5 (PP5) were examined in maternal serum and placental tissue in early and late pregnancy. The circulating concentration of hPL, SP 1 , and PP5 were higher during late pregnancy than early pregnancy, that of hCG lower, and ferritin (PP2) levels showed no difference. Placental tissue levels of hPL and SP 1 were higher in late pregnancy, hCG levels lower, and ferritin (PP2) and PP5 showed no change. The ratio of the concentration in maternal serum to that in placental tissue increased during pregnancy for all proteins with the exception of ferritin. It is proposed that the mechanism of secretion of trophoblast specific proteins varies widely and that this should be taken into account in the clinical interpretation of circulating levels in the mother.