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CONCENTRATIONS OF THE PROSTACYCLIN METABOLITE, 6–KETO–PROSTAGLANDIN F 1α , IN AMNIOTIC FLUID DURING LATE PREGNANCY AND LABOUR.
Author(s) -
Mitchell M. D.,
Keirse M. J. N. C.,
Brunt Jane D.,
Anderson Anne B. M.,
Turnbull A. C.
Publication year - 1979
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1979.tb10609.x
Subject(s) - prostacyclin , metabolite , amniotic fluid , alpha (finance) , prostaglandin , pregnancy , endocrinology , medicine , gestational age , fetus , obstetrics , andrology , biology , surgery , genetics , construct validity , patient satisfaction
Summary Concentrations of 6–keto–prostaglandin F 1α (6–keto–PGF 1α , the stable metabolite of prostacyclin, PGI 2 ) have been measured in amniotic fluid obtained during late pregnancy and labour. Samples taken at amniotomy during spontaneous labour contained a significantly greater concentration of 6–keto–PGF 1α than samples taken at amniotomy before the onset of labour (p <0.01). There was no correlation between the level of 6–keto–PGF 1α , in amniotic fluid before labour and gestational age (p > 0 1). It is suggested that prostacyclin may have a functional role in the mechanism of parturition in man.