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PLASMA LEVELS OF OESTRONE, OESTRADIOL AND GONADOTROPHINS IN POSTMENOPAUSAL WOMEN AFTER ORAL AND VAGINAL ADMINISTRATION OF CONJUGATED EQUINE OESTROGENS (PREMARIN)
Author(s) -
Englund Doris E.,
Johansson E. D. B.
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb15860.x
Subject(s) - postmenopausal women , medicine , estrone , endocrinology , estrogen , gynecology
Summary Peripheral plasma from five postmenopausal women was analyzed for oestrone and oestradiol during 48 hours after administration of 1‐25 mg Premarin (conjugated equine oestrogen) orally and vaginally. Oestrone and oestradiol were separated on columns of Sephadex LH 20 before radioimmunoassay. Administration of 1.25 mg of Premarin produced a marked increase in plasma oestrone levels and 24 hours after treatment the oestrone levels were still above follicular phase levels. The plasma pattern of oestradiol was similar but the elevation was less pronounced. The biological activity of Premarin as indicated by depressed gonadotrophin levels was similar with the intravaginal and oral routes of administration.