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SECRETION PATTERNS OF PLASMA‐PROGESTERONE, 17‐HYDROXYPROGESTERONE, AND 20α HYDROXYPREGN‐4‐EN‐3‐ONE IN EARLY ABNORMAL PREGNANCY
Author(s) -
Harrison R. F.,
Youssefnejadian E.,
Brodovcky Hilary,
Johnson M.,
Dewhurst John
Publication year - 1978
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1978.tb15855.x
Subject(s) - hydroxyprogesterone , pregnancy , hormone , medicine , endocrinology , secretion , abortion , gestation , biology , steroid , genetics
Summary Plasma progesterone, 17‐hydroxyprogesterone, 20α hydroxypregn‐4‐en‐3‐one levels were determined twice weekly up to 16 weeks gestation, where possible, in a twin pregnancy, in two patients who aborted spontaneously and in three patients who were treated with‘progesterone supplements’because of abnormal vaginal cytology. There was no correlation between vaginal smears and the plasma hormone levels and there was no evidence to suggest that progesterone supplements influenced clinical outcome. Compared with normal mean values the only difference was a significant rise in progesterone and 20a hydroxypregn‐4‐en‐3‐one levels in the twin pregnancy after the 12th week and a precipitate fall in all hormone levels just prior to abortion. Plasma hormone levels could not be used to predict outcome.